Attempt to Immunize Guinea Pigs Against Leukemia by Skin Scarification with Leukemic Cell Suspensions

Attempt to immunize guinea pigs against leukemia by skin scarification with leukemic cell suspensions.

An attempt was made to immunize "strain 2" guinea pigs by superficial skin scarification with small doses of L2C leukemic cell suspensions. Among 203 scarified guinea pigs, 32 developed progressively growing leukemic tumors at the site of skin scarification. In 35 guinea pigs small intradermal tumors that appeared at the site of scarification regressed spontaneously; however, 15 guinea pigs in ...

Isolation and characterization of a herpesvirus from leukemic guinea pigs.

A guinea pig herpesvirus (GPHV) has consistently been isolated from leukemic lymphoblasts of strain-2 guinea pigs. GPHV is serologically related to the guinea pig herpes-like virus isolated by Hsiung and Kaplow. The virions of GPHV consist of an icosahedral capsid containing a dense nucleoprotein core enclosed in a double-layered membrane. The average diameters of GPHV virion and capsid were 16...

Leukemic reticuloendotheliosis (hairy cell leukemia).

Inheritance in Guinea Pigs of the Susceptibility to Skin Sensitization with Simple Chemical Compounds

It has proved possible to set up lines of guinea pigs of significantly different susceptibilities towards a compound of simple structure, namely 2:4 dinitrochlorobenzene. This provides direct evidence that the type of sensitization under discussion is influenced by heredity.

Skin melanoma induced by 7,12-dimethylbenzanthracene in albino guinea pigs and its similarities to skin melanoma of humans.

A model for a metastasizing melanoma was developed, and its characteristics were established. Sixty-five albino guinea pigs were painted with 7,12-dimethylbenzanthracene in acetone. There was evidence that, after 18 months, 40% of the animals developed melanomas. Melanomas arose by a malignant transformation of junctional nevus cells and/or by transformation of amelanotic melanocytes. Metastase...